Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.
Status:
Recruiting
Trial end date:
2021-07-01
Target enrollment:
Participant gender:
Summary
Thiazide diuretics have demonstrated favorable blood pressure lowering efficacy, safety
profile and low cost, but it is still unclear what are the equivalence of doses of their more
common agents, chlorthalidone and hydrochlorothiazide. Besides, concernments about adverse
metabolic effects such as hypokalemia, hyperglycemia and hyperlipidemia do exist, which may
be attenuated with the concomitant administration of a potassium-sparing diuretic, such as
amiloride. In addition to control adverse effects of thiazides, amiloride could offer an
additional blood pressure lowering effect, but the efficacy of different doses was not fully
established. This study aims to investigate the blood pressure lowering efficacy of
chlorthalidone and hydrochlorothiazide, in combination with amiloride in different doses, for
the initial management in patients with primary hypertension.