Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study
Status:
Completed
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to compare two methods of post-delivery stabilization
and subsequent early respiratory care for reducing the need for MV and related secondary
complications, such as BPD, in premature babies at high risk of RDS:
1. Early stabilization on nCPAP
2. Intubation, prophylactic surfactant (Curosurf®) administration shortly after delivery,
and rapid extubation to nCPAP.
The data obtained from this comparison will be applied to test the hypothesis that preterm
neonates at risk of RDS who are treated with prophylactic surfactant + nCPAP show less need
for MV when compared to infants who receive nCPAP alone.