Efficacy of Dapagliflozin in Early Diabetic Nephropathy in Type 1 Diabetes
Status:
ACTIVE_NOT_RECRUITING
Trial end date:
2026-10-01
Target enrollment:
Participant gender:
Summary
Diabetic kidney disease (DKD) is a leading cause of chronic and end-stage kidney disease, affecting 25-40% of type 1 diabetes (T1D) patients and 5-40% of type 2 diabetes (T2D) patients. Despite standard treatments like ACE inhibitors and ARBs, many patients continue to develop DKD, indicating a need for better kidney protection. This study aims to evaluate the efficacy and safety of dapagliflozin combined with insulin in early DKD patients with T1DM, using ACEi/ARB as standard treatment, to provide new insights into kidney protection and support precision medicine goals.
Phase:
PHASE4
Details
Lead Sponsor:
The First Affiliated Hospital with Nanjing Medical University