Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agent

• Status: Unknown status
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study the investigators will submit patients with treatment resistant depression to deep anesthesia with isoflurane to get 15 minutes of cortical burst suppression on electroencephalogram, once a week for six weeks. The follow up will be for 6 months. The aim is to evaluate the change in depression severity during the entire period.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo
• Collaborator: Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Anesthetics; Antidepressive Agents; Isoflurane; Sertraline

Criteria

Inclusion Criteria:

• Patients with Treatment resistant depression on depressive state with or without psychiatric comorbidities for anxious features

• moderate to severe condition measured by Montgomery Asperger Depression Rating Scale and Hamilton Depression rating scale - 17

• be between 18 and 60 years old

• IF female, do not be pregnant and use a trustable contraceptive method

• can read and write in Portuguese language

• will to be in all the phases of the study

• have agreed with free will to participate

• classified as American Society of Anesthesiologists - Physical Status 1 or 2 by a certified anesthesiologist

• Suicide ideation measured by Montgomery Asperger Depression Rating Scale on item 10 less than 4

Exclusion Criteria:

• drug abusers in the last 6 months, except for nicotine

• use of benzodiazepines or lamotrigine less then 15 days from the first session

• family history of malignant hyperthermia Suicidal ideation on item 10 of Montgomery Asperger Depression Rating Scale more than 4

• Suicide attempt one month prior the study begins