Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chulalongkorn University
• Treatments: Dexamethasone

Criteria

Inclusion Criteria:

• Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test)

• And still in febrile phase (Body temp>37.5 C)

• Shock : Sys<90mmHg or Narrow PP (<20mmHg) orTachycardia (pulse>100/min) with Hematocrit decreased ≥20 %

• Fluid accumulation and respiratory distress

• Severe bleeding

• Severe organ involvement

Exclusion Criteria:

• Severe dengue> 24 hrs

• Dengue without warning signs

• Pregnancy

• Patient who receieved any steroid within 1 week