Efficacy of Dienogest Versus Oral Contraceptive Pills on Pain Associated With Endometriosis
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Endometriosis is a chronic inflammatory disease, frequently associated with dysmenorrhea,
dyspareunia and abdomino-pelvic pain limiting quality of life. Most medical therapies aim to
alleviate the severity of symptoms. Recent guidelines recommend the use of either OCPs or
progestins as a first-line treatment of pain associated with endometriosis. The effectiveness
of both OCPs and dienogest, a fourth-generation progestin, for endometriosis treatment has
been demonstrated. The literature is rich with data comparing the use of Visanne or OCPs to
placebo or GnRH analogs. However, there are no head to head studies comparing their efficacy
in the management of endometriosis associated pain. The study aims to evaluate if Dienogest
(Visanne) is not inferior in efficacy to oral contraceptive pills (Yasmin) in controlling
pain associated with endometriosis?