Efficacy of Dietary Sodium Restriction of Improving Vascular Endothelial Function in Middle Aged and Older Adults

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that reducing salt in the diet will improve the function of blood vessels in middle aged and older adults with moderately elevated systolic blood pressure, by increasing the amount of BH4 and nitric oxide in your blood vessels and reducing the amount of oxidative stress.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Colorado, Boulder
• Collaborator: National Institute on Aging (NIA)

Criteria

Inclusion Criteria:

• 50-79 years of age

• SBP 130-159 mmHg

Exclusion Criteria:

• Have been sick with an infection in the past two weeks

• Are currently sick or have ongoing health problems such as kidney or CVD

• Have lost more than 11 lbs. in the last 3 months

• Are taking any type of antioxidants

• Smoke or have alcohol problems

• Have blood glucose levels higher than 126 mg/dL

• Have resting SBP below or less than 100 mmHg or greater than 159 mmHg

• Have a resting diastolic blood pressure greater than 99 mmHg

• Have a BMI greater than 40 kg/m^2

• Are presently consuming less than 9 or greater than 18 grams of salt / day

• Have a baseline FMD of greater than 6%

• Are taking any of the following types of drugs: blood thinners, anti-seizure medications, ant-inflammatory drugs

• Participate in any high endurance athletic training

• Taking Hormone Replacement Therapy

• Have not been post-menopausal for at least 1 year