Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
This pilot study will investigate the feasibility of conducting a large, randomized trial
comparing a structural intervention to contingency management to reduce incident syphilis
infections in an especially high risk group: HIV+ men who have sex with men (MSM) who have
had syphilis twice or more since their HIV diagnosis. Subjects will be randomized to receive
either QD doxycycline as syphilis prophylaxis or a financial incentive to remain STI free.
The investigators will : 1) measure adherence to study visits in both arms; 2) measure
adherence to the prophylaxis regimen; 3) measure any changes in risk behaviors among study
participants and 4) to the extent possible in a small pilot study of short duration, compare
effectiveness of doxycycline with that of a monetary incentive for remaining STI free.