Efficacy of Duloxetine Compared to NSIADs in Osteoarthritis of Knee

• Status: Not yet recruiting
• Trial end date: 2023-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 25% of the population . Knee OA is an insidious disease related to structural changes in the joint over many years. Progressive articular damage results in a loss of the extracellular matrix of cartilage in addition to changes in subchondral bone.

Duloxetine, a selective serotonin, and norepinephrine reuptake inhibitor, it seems to be effective in treating neuropathic and chronic pain conditions.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hawler Medical University
• Treatments: Duloxetine Hydrochloride

Criteria

Inclusion Criteria:

1. > 40years of age

2. both Genders

3. who will meet the American College of Rheumatology clinical and radiographic criteria for the diagnosis of osteoarthritis of the knee

4. with pain for ≥14days of each separate month for 3months before study entry, with a mean score ≥4 on the 24-h average pain score (0-10) using the average of daily ratings

Exclusion Criteria:

1. if they have diagnosed with inflammatory arthritis or an autoimmune disease

2. if they received invasive therapy in last 3 months (knee arthroscopy) or knee replacement at any time

3. patients with psychiatric disorders

4. Hypertension

5. Heart disease

6. patients on antipsychotics or anti-depressant -