Overview

Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain

Status:
Not yet recruiting

Trial end date:
2023-12-01

Target enrollment:
0

Participant gender:
All

Summary

Cancer pain is one of the most common and problematic symptoms. Opioids are typically the most common drugs used in the treatment of cancer pain,they are limited due to their side effects. Tramadol is a centrally acting non-opiate analgesic with low affinity for μ-opioid receptors, and is effective in the treatment of moderate to severe pain. Neuropathic pain is typically not amenable to standard opiate therapy, and the addition of tricyclic antidepressants or/and antiepileptic drugs can offer a very effective treatment strategy in such patients. Duloxetine is a Serotonin Norepinephrine Reuptake Inhibitor (SNRI) that has been used traditionally for its antidepressant qualities and has also analgesic benefit in the treatment of neuropathic pain. Duloxetine exerts its analgesic action through central and peripheral pain modulation .

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Assiut University

Treatments:

Duloxetine Hydrochloride
Tramadol

Criteria

Inclusion Criteria:

- Patients with cancer pain

1. age from 20-70 years old.

2. not receiving any type of analgesia before (opioid naïve, no adjuvants).

Exclusion Criteria:

1. Difficult to be assessed for pain.

2. Any contraindication for duloxetine or tramadol.