Efficacy of EGF-loaded Self Healing Gel in Treatment of Oral Mucositis
Status:
Not yet recruiting
Trial end date:
2022-12-30
Target enrollment:
Participant gender:
Summary
Cancer treatment, including radiation along with aggressive chemotherapy, increases the
patient's survival rate. However, they possess toxic side effects. Oral mucositis is one of
the most serious complications of cancer treatment, which occurs in most of patients
receiving cancer therapy. Mucositis can dramatically affect the patient's quality of life
.Epidermal growth factor (EGF) is a dominant factor in early keratinocyte differentiation,
proliferation and migration. However, a major obstacle in most studies is that there isn't
prolonged contact between the applied treatment and the oral mucosa to achieve the optimum
therapeutic effect. Thus, a new vehicle for EGF is needed to achieve sufficient prolonged
contact with oral mucosa. The present project aims at employing EGF as therapeutic agent for
mucositis dealing with the challenges of delivery of such macromolecule to the oral mucosa by
using self-healing gels to maximize the drug effect.