Efficacy of Epidiolex in Patients With Electrical Status Epilepticus of Sleep (ESES).
Status:
Recruiting
Trial end date:
2022-10-01
Target enrollment:
Participant gender:
Summary
This study aims to assess the efficacy of Epidiolex in patients with ESES. ESES is
characterized by sleep potentiated spikes with a spike index greater than 85% (conventional
definition) and 50% (new definition)1. Several drugs including: steroids, intravenous Gama
globulin, Clobazam, other benzodiazepines, Valproic acid, and other anti-epileptic drugs have
been tried with mixed benefits2,3. Cannabidiol (CBD) would provide a novel mechanism of
action to assess for its efficacy in this population. This will be a double-blind
placebo-controlled crossover clinical trial.