Overview

Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients

Status:
Completed
Trial end date:
2018-03-13
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to evaluate the efficiency of SSRIs（Selective Serotonin Reuptake Inhibitor） ,ERP（Exposure and Response Prevention） and the combination of the two therapies for OCD(Obsessive-Compulsive Disorder) patients ,at the same time, to find out the biological or psychological predictors of treatment response in Chinese population.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Shanghai Mental Health Center
Collaborators:
Shanghai Jiao Tong University School of Medicine
Shanghai Municipal Science and Technology Commission
Treatments:
Citalopram
Dexetimide
Fluoxetine
Fluvoxamine
Paroxetine
Serotonin
Serotonin Uptake Inhibitors
Sertraline
Criteria
Inclusion Criteria:

- Having been diagnosed with primary OCD as defined by the Diagnostic and Statistical
Manual of Mental Disorders (DSM-IV-) criteria;Cleaning or checking as primary OCD
symptoms

- Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score of ≥ 16

- Never receiving adequate treatment or stop receiving treatment for at least 8 weeks

- Having an education degree of high school or above

- Accepting to participate in the study

Exclusion Criteria:

- Having significant medical illnesses that would interfere with the conduct of the
study

- Clinically significant abnormal laboratory finding

- Having comorbid psychiatric conditions according to the criteria set forth in the
DSM-IV(administered by the Mini-International Neuropsychiatric Interview (MINI))

- The current OCD symptoms are too severe that the patient cannot finish the evaluation
or receive the ERP

- Being currently at risk for suicide

- Being pregnant or having the intention to be pregnant before the end of the study

- A history of having inadequate response to adequate SSRIs or CBT treatment

- Subjects who are unable to undergo the MRI