Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children
Status:
Completed
Trial end date:
2006-07-01
Target enrollment:
Participant gender:
Summary
There is a necessity for the development of new malaria drugs. Some antibiotics are also
effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be
effective against malaria, although it cannot achieve a total cure in all patients. Previous
small studies have shown that in combination with clindamycin, an commonly used antibiotic,
it is highly effective and safe when given for three days, leading to a total cure in most
patients. The current study will evaluate its efficacy in a larger population in Gabon, and
compare its effect with the generally used drug, sulfadoxine-pyrimethamine.