Efficacy of Four Different Treatment Regimes on Postpartum Hemorrhage: A Multicentric Randomized Controlled Trial

• Status: Recruiting
• Trial end date: 2023-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

Postpartum hemorrhage is the most important cause of maternal morbidity and mortality worldwide and accounts for approximately 25% of deaths worldwide. Drugs such as oxytocin, carbetocin and tranexamic acid are used for bleeding control after normal vaginal delivery. The most widely used agent for the prevention of postpartum hemorrhage worldwide is oxytocin. The primary aim of our study is to reduce the mean blood loss after vaginal delivery. In this study, we aimed to compare the efficacy of carbetocin alone in the 1st group, oxytocin alone in the 2nd group, carbetocin and tranexamic acid in the 3rd group, and oxytocin and tranexamic acid in the 4th group in preventing postpartum blood loss originating from the uterus.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bezmialem Vakif University
• Treatments: Carbetocin; Oxytocin; Tranexamic Acid

Criteria

Inclusion Criteria

• Single pregnancy greater than 37 weeks

• Pregnant women between the ages of 18-40

• Volunteer

Exclusion Criteria:

• Pregnancy less than 37 weeks

• Patients under stress who cannot give informed consent

• Patients allergic to carbetocin, oxytocin or tranexamic acid

• Clinical diagnosis of a serious cardiovascular disease

• Clinical diagnosis of severe liver disease

• Clinical diagnosis of kidney disease

• Clinical diagnosis of epilepsy

• Internal feature with risk for embolism or bleeding

• Refusing to volunteer