Efficacy of G-CSF in the Management of Steroid Non-responsive Severe Alcoholic Hepatitis

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

After successful screening, first the investigators first treat patients of severe alcoholic hepatitis with steroids for 7 days. Patients who are found to be unresponsive as per Lille's score [>0.45] would be randomized into either placebo group or G-CSF group. Responders to steroids will continue on steroids for 28 days followed by 2 weeks of tapering. Non responders will be randomized to receive G-CSF for 28days.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institute of Liver and Biliary Sciences, India
• Treatments: Lenograstim

Criteria

Inclusion Criteria:

• Severe alcoholic hepatitis patients [Maddrey's score > 32] aged between 18 to 65 years.

Exclusion Criteria:

• Presence of active infections

• Acute GI bleed

• Hepatorenal syndrome

• Patient unwilling

• DF>120

• Autoimmune hepatitis

• Hepatitis B, Hepatitis C, HIV cases

• Pregnancy