Efficacy of Gabapentin in Prevention of Tourniquet Pain and Hypertension

• Status: Withdrawn
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to find out if taking a dose of gabapentin 600 mg by mouth (po) before surgery will help prevent the development of tourniquet pain and hypertension while the tourniquet is inflated during orif of tibia fracture.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Baylor College of Medicine
• Treatments: Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• Patient ages 18-64

• ASA physical status 1-3

• Schedule for orif tibia fracture with use of pneumatic tourniquet

Exclusion Criteria:

• Allergy to study medications

• polytrauma

• lower extremity crush injury

• chronic opioid use

• sickle cell disease or trait

• peripheral vascular disease

• poorly controlled hypertension

• history of DVT/PE

• morbid obesity (BMI > 35)

• patient or surgeon refusal

• patient inability to properly describe postoperative pain to investigators