Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation

• Status: Unknown status
• Trial end date: 2008-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy of glycerol ointment, triamcinolone acetonide ointment, clobetasol ointment and tacrolimus ointment on irritated skin in a cumulative skin irritation test model using healthy volunteers.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Odense University Hospital
• Collaborators: LEO Pharma; University of Southern Denmark
• Treatments: Clobetasol; Glycerol; Immunologic Factors; Mineral Oil; Tacrolimus; Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• caucasian

• normal skin on both volar forearms

• oral and written informed consent

Exclusion Criteria:

• pregnant, lactating women

• no safe anticonceptive method used

• intake of systemic immunosuppressants (e.g. prednisolone)

• endocrine, immune, or liver disorders

• known allergy towards drugs applied to the skin