Efficacy of Herbal Dentifrice for Management of Dentinal Hypersensitivity
Status:
Not yet recruiting
Trial end date:
2023-08-15
Target enrollment:
Participant gender:
Summary
- Recently, Herbal formulations have gained wide popularity in management of Dentinal
hypersensitivity owing to the additive effects of active anti-inflammatory ingredients
like Curcuma longa, Clove oil, Acacia arabica and Spinach leaves in addition to
desensitizing ingredients like Potassium nitrate and/or Sodium fluoride.
- Jasmate herbal formulations which contains Potassium Nitrate along with aqua, calcium
carbonate, sodium cocoyl glutamate, sorbitol 70%, glycerin, curcuma longa, arginine
hydrochloride, erythritol, sodium saccharin, hydrated silica, sodium carboxymethyl
cellulose, elettaria cardamomum, foeniculum vulgare, melaleuca leucadendra, eucalyptus
globules, aloe barbadensis, carnosic acid, zinc oxide, hydroxyapatite, propolis,
hippophae rhamnoides, syzygium aromaticum, myrtus communis, sodium benzoate and sodium
fluoride7, where such formulations claim to have an anti-inflammatory action due to the
active ingredient i.e. curcuma longa which further reduces the DH and have a synergistic
effect.
- Efficacy of desensitizing preparations containing the above ingredients, in the form of
Jasmate was tested in the laboratory along with BioMin F and results were encouraging
with sufficient occlusion of the dentinal tubules in both the groups without
statistically significant differences in the results.
- The biocompatibility (cytotoxicity) of Jasmate toothpaste preparation was evaluated in
the laboratory by using human gingival fibroblasts at different concentrations.
Different tests like cell cycle analysis, apoptosis / necrosis and MTT were done and
Jasmate toothpaste preparation showed the lowest cytotoxicity as compared to BioMin F
toothpaste preparation. Jasmate toothpaste preparation showed more than 92% of live
cells in all concentrations.
- The current randomized controlled clinical trial will be conducted to evaluate safety
and efficacy of Jasmate toothpaste preparation in the management of DH post scaling and
root planing in patients with chronic periodontitis.