Efficacy of Hyaluronic Acid and Platelet-rich Plasma Combination in Knee Osteoarthritis

• Status: Completed
• Trial end date: 2021-03-27
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the efficacy of intra-articular injections of combined hyaluronic acid and platelet-rich plasma in knee degenerative joint disease in improving joint function and reducing pain.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Milan
• Collaborator: Regen Lab SA
• Treatments: Hyaluronic Acid

Criteria

Inclusion criteria:

• Knee pain for 4 months;

• Knee degenerative sign evaluated with X-ray with a Kellgren-Lawrence grade inferior to 3;

• Patients able to understand the study conditions and willing to participate for its entire duration;

• Patients who signed written informed consent.

Exclusion criteria:

• Severe knee osteoarthritis of grade 4;

• Diabetes mellitus;

• Rheumatoid arthritis;

• Ongoing malignancies;

• Certified allergic reactions towards the administered drugs ;

• Malalignment of mechanical axis of the lower limb (varus > 10 °, valgus > 10 °);

• Coagulopathies;

• Severe cardiovascular diseases;

• Ongoing infections;

• Immunodepression;

• Anticoagulants or anti-platelet agents;

• Haemoglobin < 11 g/dl;

• Platelet count < 150,000/mm^3

• Drug addiction;

• Alcoholism;

• Psychiatric disease;

• Pregnancy or breastfeeding.