Efficacy of Intensive Cholecalciferol Monitoring and Supplementation on Serum vitD Levels in Pediatric Patients With CF
Status:
Recruiting
Trial end date:
2023-09-30
Target enrollment:
Participant gender:
Summary
Cystic fibrosis (CF) is an autosomal recessive disease caused by alterations in the Cystic
Fibrosis Transmembrane Conductance Regulator (CFTR) gene, characterized by multisystemic
alterations, mainly in the lung, intestine, sweat, and bile ducts. In addition to pulmonary
involvement, the presence of exocrine pancreatic insufficiency also increases the risk of
survival, as it is associated with malnutrition and deficiency of fat-soluble vitamins, such
as vitamin D.
Vitamin D, in addition to its role in bone health, in the case of CF patients with chronic
inflammation, it has been suggested that many of the cytokines that regulate the inflammatory
response contain elements that respond to vitamin D, so vitamin D could play an essential
role in the regulation of the inflammatory response in CF, which could favor lung function.
However, more than 50% of CF patients present vitamin D insufficiency or deficiency, despite
the different schemes suggested for supplementation in different age groups, which suggests
that new strategies are needed to normalize vitamin D levels, which will allow us to see its
clinical effect on the inflammatory response, by decreasing the number of exacerbations and
thus perpetuating or improving lung function, as well as on bone mineral health.