Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria
Status:
Unknown status
Trial end date:
2004-01-01
Target enrollment:
Participant gender:
Summary
Cerebral malaria is the most lethal complication of P.falciparum infection with a mortality
rate between 5 and 40%. Intravenous quinine remains the recommended treatment for cerebral
malaria. However its administration is often not feasible due to lack of simple equipment or
trained staff. When referral is not possible, a viable alternative is needed. The intrarectal
route is of interest in children since it is painless and simple. Studies of the efficacy of
intrarectal quinine in the treatment of cerebral malaria are limited. The study aims to
establish the efficacy of intrarectal quinine in the treatment of childhood cerebral malaria.