Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
The primary objective is to compare the efficacy of irbesartan/hydrochlorothiazide 300/25mg
against valsartan/hydrochlorothiazide 160/25mg in reducing mean systolic blood pressure (SBP)
as measured by home blood pressure monitoring (HBPM) after 24 weeks compared with baseline.
The secondary objectives are:
- To compare the percentage of patients with normal blood pressure as measured by HBPM and
at the doctor's office at weeks 16 and 24
- To compare the differences in mean Diastolic Blood Pressure (DBP), mean morning and
evening SBP and DBP evaluated by HBPM at weeks 16 and 24
- To compare the difference in mean SBP evaluated by HBPM at week 16
- To compare the differences in mean SBP and DBP evaluated at the doctor's office at weeks
16 and 24
- To determine the incidence and severity of adverse events