Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus

• Status: Withdrawn
• Trial end date: 2021-05-18
• Target enrollment: 0
• Participant gender: All

Summary

The study will investigate the efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as a first line agent in refractory status epilepticus versus traditional general anesthetic agents used for burst suppression that target the gamma-aminobutyric acid adrenergic receptors.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Anticonvulsants; Ketamine; Propofol

Criteria

Inclusion Criteria:

• Patients more than 18 years of age with a diagnosis of status epilepticus

• Considered for burst suppression therapy after failing 2 or 3 anti-epileptic medications

Exclusion Criteria:

• Post anoxic status epilepticus

• Pregnant women, as confirmed by urine, or blood human chorionic gonadotropin, ultrasound or physical exam

• Prisoners

• Age less than 18 years

• Allergy or sensitivity to the drug in question