Efficacy of L-menthol on Breathlessness in Chronic Obstructive Pulmonary Disease

• Status: Not yet recruiting
• Trial end date: 2024-12-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the effect of L-menthol on breathlessness in patients with chronic obstructive pulmonary disease (COPD).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Region Skane
• Collaborator: Lund University
• Treatments: Menthol

Criteria

Inclusion Criteria:

• The subject has given written consent to participate in the study

• Diagnosis of COPD confirmed by spirometry and a FEV1 < 80% of predicted post bronchodilator at baseline

• age 18 years or older

• able to cycle

• able to understand and talk Swedish to participate in the study procedures, as judged by the Investigator.

Exclusion Criteria:

• Resting peripheral oxygen saturation (SpO2) < 92%

• hospitalization or clinical instability during the last four weeks

• treatment with supplementary oxygen at rest or during exercise

• contraindication to exercise testing in accordance with clinical practice guidelines

• expected survival shorter than six months as judged by the Investigator

• medical conditions including congestive heart failure, acute coronary artery disease, neuromuscular diseases, severe psychiatric illness, and olfaction disorder.