Efficacy of Lansoprazole in Chronic Post Nasal Drip

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether aggressive acid suppression with Lansoprazole is effective in the treatment of post nasal drip, and also assess the predictors of response based on clinical and physiologic parameters.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University; Vanderbilt University Medical Center
• Collaborator: TAP Pharmaceutical Products Inc.
• Treatments: Dexlansoprazole; Lansoprazole

Criteria

Inclusion Criteria:

• Negative RAST inhalant allergy panel OR negative skin testing (Group A)

• Positive RAST or Positive skin testing AND insufficient response to all of the following: (Group B)

• Allergen avoidance

• Topical nasal steroids

• Allergy shots if indicated

• Antihistamines

• Negative CT sinuses (coronal)

• < 4mm of mucosal thickening and < 3 sinus sites

• Absence of air-fluid levels

• Negative anterior rhinoscopy

• Absence of pus, crusts on mucosal surfaces

Exclusion Criteria:

• Age < 18

• Pregnancy, confirmed by urine pregnancy test at day of randomization

• Ciliary dyskinesia

• Immune deficiency

• Cystic fibrosis

• Diagnosis of acute sinusitis or chronic RS (AAO-HNS)

• Active use of topical decongestant

• Use of PPI within the last 30 days

• Previous fundoplication

• Uncontrolled thyroid disease

• Isolated chronic cough without the symptom of post nasal drip