Efficacy of Levocetirizine and Cetirizine in Reducing Symptoms of Seasonal Allergic Rhinitis in Ragweed Sensitive Subjects

• Status: Completed
• Trial end date: 2004-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Controlled conditions of the EEU allow a reliable assessment of the efficacy and a determination of the action onset, action intensity and duration of effect of levocetirizine and cetirizine in order to establish the relative efficacy of these two drugs available for the treatment of SAR.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: UCB Pharma
• Treatments: Cetirizine; Levocetirizine

Criteria

Inclusion Criteria:

• Male/Female, aged >= 16 years

• seasonal allergic rhinitis that required pharmacologic therapy each year during the last 2 ragweed pollen seasons

• documented seasonal allergy to ragweed pollen

• total symptom score of at least 18 points.

Exclusion Criteria:

• nasal anatomic deformities ? 50% obstruction

• acute sinusitis within 30 days of Period 2

• initiated or advanced an immunotherapy regimen

• immunotherapy injections within 48 hours of pollen exposure

• impaired hepatic function

• history of malignancy

• intolerance to histamines

• asthma requiring medication more than occasionally