Efficacy of Locally Delivred 1.2% Rosuvastatin Gel in Chronic Periodontitis
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
BACKGROUND: Chronic periodontitis (CP) is an inflammatory condition affecting tooth
supporting tissues and alveolar bone that surround the tooth leading to formation of deepend
gingival sulcus that is highly prone to pathologic changes, ultimately bone resorption and
tooth loss. In the literature, several pharmacologic agents have been administration via
local delivery route, directly into diseased sites affirming greater improvement in
periodontal status. Therefore, present study was conducted to determine the clinical
effectiveness of subgingivally delivered 1.2% Rosuvastatin gel incorporated into an
methylcellulose vehicle for its controlled release into intrabony defect sites in adjunct to
scaling and root planing for treatment of chronic periodontitis patients.
MATERIAL AND METHODS: Sixty five patients were categorized into two treatment groups: group I
-SRP plus RSV, 1.2 mg and group II -SRP plus placebo. Clinical parameters included modified
sulcus bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL), were
recorded at baseline before SRP and at 1, 3, 4, and 6 months. Radiologic assessment of
intrabony defect (IBD) fill was analysed at baseline and after 6months using computer-aided
software.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Government Dental College and Research Institute, Bangalore