Efficacy of Losartan in Preventing Progression of COPD

• Status: Completed
• Trial end date: 2016-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Evidence in animals shows that losartan can prevent or reverse inflammation and lung damage due to smoking. The goal of this study is to determine whether this drug which is also used to treat hypertension can stabilize or improve lung function in people who have from chronic obstructive pulmonary disease (COPD).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johns Hopkins University
• Collaborators: Merck Sharp & Dohme Corp.; National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Losartan

Criteria

Inclusion Criteria:

• Adults with COPD who are either active or former smokers

Exclusion Criteria:

• Clinical requirement or history of intolerance of angiotensin receptor blockers, serious heart, liver, kidney, neurological disease.