Efficacy of Metformin and Diane-35 on PCOS Patients,a Randomized, Controlled, Prospective Clinical Trial
Status:
Completed
Trial end date:
2013-02-01
Target enrollment:
Participant gender:
Summary
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in
reproductive-age women, and it affects 5-7% of this group. It is characterized by disturbed
menstrual cycle, ovulatory dysfunction and hyperandrogenism. Over 40% of PCOS women might
become the patients with impaired glucose tolerance or type 2 diabetes. It has been confirmed
that insulin resistance (IR) is a common feature in PCOS and adipokines might play roles in
the pathogenesis of IR and PCOS, because these adipokines have wide-ranging effects on
carbohydrate and lipid metabolism.
The present clinical trial intends to compare the effects of metformin and oral
contraceptives on PCOS patients, focusing on the insulin sensitivity, ovulation, and
menstrual cycle etc. The investigators also aim to study the effects of metformin on serum
adipokine levels(such as pigment epithelium-derived factor, progranulin etc.)in PCOS
patients.