Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients
Status:
Recruiting
Trial end date:
2022-08-12
Target enrollment:
Participant gender:
Summary
At present, there are no FDA-approved treatments for chemotherapy-induced PN .furthermore,
the exact mechanism of PN is incompletely understood, however, several potentials include
inflammation, promotion of microtubule polymerization and inhibition of depolymerization, and
oxidative stress. Discrete neuro anti-inflammatory effects of metformin support its
repurposing as a neuroprotective agent in patients with neurodegenerative diseases. Numerous
in vitro and in vivo studies have confirmed that metformin ameliorates oxidative damage.
Therefore, this study aims to evaluate the effect of metformin on the amelioration of
paclitaxel induced PN in breast cancer patients.