Efficacy of Metformin as add-on Therapy in Non-Diabetic Heart Failure Patients
Status:
Recruiting
Trial end date:
2022-12-30
Target enrollment:
Participant gender:
Summary
There is an increasing interest in the use of metformin in CV diseases and there is an
increasing interest in studying its potential new roles in heart failure patients. There were
some concerns related to the safety of metformin in such diabetic patients due to the risk of
lactic acidosis. However, recent studies showed that metformin was safe or even beneficial in
HF patients. We hypothesized that metformin might improve morbidity, mortality, cardiac
function, and HR-QoL in non-diabetic patients with HFrEF.