Efficacy of Midodrine for the Prevention of Orthostatic Hypotension During Early Mobilization After Fast-track Hip Arthroplasty

• Status: Completed
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to examine the efficacy of 5 mg Midodrine (Gutron) vs. placebo on reducing the incidence of orthostatic hypotension during mobilization 6 h after a total hip arthroplasty.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Treatments: Midodrine

Criteria

Inclusion Criteria:

• Scheduled for primary unilateral hip arthroplasty

• Age >= 18 years

• Able to give informed consent

Exclusion Criteria:

• General anaesthesia for the current procedure

• Digoxin treatment.

• history of renal or hepatic failure

• history of glaucoma

• history chronic urinary retention requiring treatment

• history of orthostatic intolerance / hypotension

• other autonomous nervous system disease

• alcohol or drug abuse

• current malignant disease

• females in the fertile age (possible pregnancy or breast feeding)

• Treatment with anticoagulants

• BMI > 40 kg/m2

• Dementia or cognitive dysfunction (investigators evaluation)