Efficacy of Monthly Ibandronate in Women With RA and Reduced Bone Mineral Density Receiving Long-term Steroids

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study was to investigate the efficacy of oral monthly ibandronate in the management of glucocorticoid induced osteoporosis in women with rheumatoid arthritis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yeong-Wook Song
• Treatments: Diphosphonates; Glucocorticoids; Ibandronic Acid

Criteria

Inclusion Criteria:

• Rheumatoid arthritis fulfilling the 1987 ACR criteria

• Women equal and above 18 years, less than 75 years old

• L1-4 T score less than -1.0 and equal or above -3.0 SD measured by DXA (Dual Energy X-ray Absorptiometry)

• Patient must have taken prednisolone 5mg or its equivalent for more than 3 consecutive months within 1 year

• Patient who would be taking glucocorticoids for more than 3 months after enrollment

Exclusion Criteria:

• Patient with vertebral fractures or nonvertebral fractures associated with osteoporosis

• Patient diagnosed with malignancy within 5 years

• Patient with endocrine dysfunction

• RA functional class 4

• Patient who took bisphosphonates within 6 months

• Patient on medication affecting bone mineral metabolism