Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Replacement

• Status: Completed
• Trial end date: 2020-03-12
• Target enrollment: 0
• Participant gender: All

Summary

An alternate perioperative pain control protocol composed of intravenous ketorolac and oral acetaminophen for patients who underwent total knee replacement was designed with the aim to determine its efficacy when compared to pain control with intravenous morphine and oral oxycodone combined with acetaminophen. In addition, the study will evaluate the differences and similarities in the Hispanic population that could predict protocol efficacy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Puerto Rico
• Treatments: Acetaminophen; Analgesics, Opioid; Ketorolac; Morphine

Criteria

Inclusion Criteria:

• Hispanic American patients undergoing primary total knee arthroplasty

• Older than 21 years of age

• Classified with an American Society of Anesthesiologist Classification (ASA) of I or II.

Exclusion Criteria:

• Hypersensitivity to any components of analgesic drugs

• Impaired renal, cardiac, or hepatic function

• Baseline serum creatinine level higher than 1.2mg/dL

• History of gastrointestinal bleeding

• Neuromuscular deformities

• Inability to consent