Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease

• Status: Completed
• Trial end date: 2012-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This clinical trial is to investigate whether nonsteroid anti-inflammatory drops have therapeutic effect on moderate to severe dry eye patients.And compare the efficacy of the two nonsteroid anti-inflammatory drops with topical corticosteroids.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wenzhou Medical University
• Treatments: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Fluorometholone; Lubricant Eye Drops

Criteria

Inclusion Criteria:

• moderate to severe dry eye syndrome

• tear film breakup time >0 second and ≤5 seconds,or schirmer test(no anaesthesia)≥2mm/5min and ≤5mm/5min

• corneal staining≥3 scores

Exclusion Criteria:

• allergic to any composition of the drugs under experiment

• previous use of anti-inflammatory drugs or immunosuppressive agent

• viral,bacterial or fungal infection of the eye

• eyelid anomaly

• glaucoma or high IOP

• significant meibomian gland dysfunction