Overview

Efficacy of Oocyte Activation With Two Types of Ca2+ Ionophore.

Status:
Recruiting

Trial end date:
2024-12-01

Target enrollment:
0

Participant gender:
Female

Summary

This study is a prospective ranzomized analysis including 372 human oocytes from 44 women. Half of the oocytes from the same patient will be randomly allocated to induce oocyte activation using two protocols: in protocol nº 1 we will use ionomycin (prepared solution), protocol nª2 A23187 (GM508 CultActive Gynemed) will be applied. Non treated oocytes will serve as control. Oocyte fertilization rates, embryo development and embryo quality will be analyzed. Obstetrics variables of offspring will be also followed and compared.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Instituto Valenciano de Infertilidad, IVI VALENCIA

Treatments:

Calcimycin
Ionomycin

Criteria

Inclusion Criteria:

- Own oocyte patients who have had previous fertilization failure in previous cycles.

- Own oocyte patients with fertilization rate in previous cycles less than or equal to
30% of the microinjected oocytes.

Exclusion Criteria:

- Oocyte Recipient Patients

- Sperm bank sperm recipient patients

- Patients who after oocyte decumulation have less than 2 mature oocytes.