Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery

• Status: Unknown status
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: All

Summary

• The primary endpoint is the effect of the addition of oral Diltiazem and Tranexamic Acid to general anesthesia aided reduction in blood loss during functional endoscopic sinus surgery (FESS).

• The secondary endpoint is surgeon's assessment of the surgical field and hemodynamics.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Diltiazem; Tranexamic Acid

Criteria

Inclusion Criteria:

include patients who undergoing elective FESS under general anesthesia and meet these criteria:

• Age from 18 - 60 years old. - ASA grade I - II.

Exclusion Criteria:

• - Patient refusal.

• Any contraindication of calcium channel blocker:

1. AV conduction defects (2nd and 3rd degree AV block).

2. Sick sinus syndrome.

3. Wolf-Parkinson-White Syndrome.

4. History of congestive heart failure.

5. Patients on long-term ß-blocker therapy.

• Patients with allergy to medication included in the study.

• Any contraindication of Tranexamic Acid:

1. bleeding disorders.

2. pregnant or breastfeeding mothers.

3. patient under the influence of anticoagulants.