Efficacy of Oral Probiotic and Antibiotic Administration in Patients With Chronic Periodontitis
Status:
Unknown status
Trial end date:
2017-03-01
Target enrollment:
Participant gender:
Summary
The aim of this randomized placebo- controlled clinical trial is to evaluate the effects of
Lactobacillus rhamnosus SP1- containing probiotic tablets and azithromycin tablets as an
adjunct to scaling and root planning (SRP).
Material and methods: Fifty-four chronic periodontitis patients will be recruited and
monitored clinically, immunologically and microbiologically at baseline, 3, 6, 9 and 12
months after therapy. All patients will receive scaling and root planning and randomly will
be assigned over an probiotic experimental (SRP + probiotic, n=18), antibiotic experimental
(SRP + Azithromycin, n=18) or control (SRP + placebo, n=18) group. Probiotic will be used
once per day during 3 months. Antibiotic will be used once per day during 5 days.