Efficacy of Oral Trigonella Foenum-graecum Seed Extract Vs Placebo in Treatment of None Alcoholic Fatty Liver Disease

• Status: Completed
• Trial end date: 2017-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study design to examine performance of trigonella foenum-graecum (TFG) in treatment of non-alcoholic fatty liver disease. Base on inclusion and exclusion criteria, 50 patients select and then randomize into intervention and control groups. Two group use capsules which contain TFG or placebo, respectively.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shiraz University of Medical Sciences

Criteria

Inclusion criteria:

• The level of ALT and AST greater than 1.5 and less than 10 times normal level

• Ultrasound evidence confirm fatty liver disease; age between 18-70 years old

• Negative pregnancy test for women in reproductive age (up to two weeks prior to the study)

• Negative for hepatitis B and C

• BMI: 18.5 to 40

• Sign the consent form.

Exclusion criteria:

• History of more than one unit of alcohol consumption (one value for the Spirits (vodka; whiskey)

• Wine and Beer are respectively 30-45 cc; 120-150 cc and 360 cc.)

• Fatty liver controller medications

• Glucose lowering drugs

• Cholesterol lowering drugs

• Hypotensive drugs

• Consumption of vitamin E

• Taking coenzyme Q10

• Administration of corticosteroids & glucocorticoids

• Thyroxin administration

• Administration of drugs that cause fatty liver

• Diabetes (type 1 and 2)

• History of cancer in the past

• Hepatocellular carcinoma

• Renal failure (creatinine> 1.5 x ULN)

• Chronic pancreatitis

• Cirrhosis

• Uncontrolled hypertension (above 180 mm Hg systolic blood pressure); heart disease

• Autoimmune hepatitis

• Primary biliary cirrhosis

• Primary sclerosing cholangitis (alkaline phosphatase levels greater than 3 times normal)

• Wilson's disease

• Alpha-1 antitrypsin deficiency and coronary artery disease

• Symptoms of hypothyroidism

• Hyperthyroidism

• Disorders of the hypothalamic - pituitary

• Liver transplantation

• Pregnant or lactating women

• Those who cannot use contraceptives.