Efficacy of Ovarian Stimulation Based on FSHR Genotype Status
Status:
Suspended
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
Available data from in vitro studies and clinical trials indicate that genetic factors play a
significant role in the success of controlled ovarian stimulation (COS) prior to in vitro
fertilization - embryo trandfer (IVF-ET). Women with the FSHR Ser680Asn Ser/Ser genotype make
up between 13% and 26% of women undergoing IVF-ET and are characterised by higher basal FSH
serum concentrations, the need for a higher amount of FSH for COS, and a higher risk of poor
response to COS and cycle cancellation.
The investigators therefore intend to perform a study to investigate whether a
dose-intensified COS protocol based on FSHR genotype status in women with the FSHR Ser680Asn
Ser/Ser genotype is more effective than routine management in terms of
- the mean number of follicles
- the mean number of embryos
- the rate of poor responders
- the rate of women with cycle cancellations, and v) the clinical pregnancy rates.
Eligible women will be randomized to a stimulation protocol characterised by a longer
duration and increased dosage of FSH stimulation (group A) or a standard stimulation protocol
(group B).