Efficacy of PRUcalopride in Critically Ill Patients With Paralytic ILeus

• Status: Recruiting
• Trial end date: 2020-02-15
• Target enrollment: 0
• Participant gender: All

Summary

Paralytic ileus is a common intestinal dysfunction in critically ill patients. There are still no established the effective medications except correcting the primary causes and prokinetics trial which limited in efficacy and potential adverse events.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Prince of Songkla University
• Treatments: Prucalopride

Criteria

Inclusion:

• Medical patients with APACHE II score >= 15

• Paralytic ileus: small bowel diameter >= 4 cm or large bowel diameter >= 6 cm

Exclusion:

• no current prokinetic use

• Severe peritonitis or bowel inflammation

• ESRD needed hemodialysis