Efficacy of Pain Control in Different Bupivacaine Dose in Periarticular Injection in Bilateral Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2020-09-14
• Target enrollment: 0
• Participant gender: All

Summary

To study efficacy of postoperative pain control of different concentrations of bupivacaine for periarticular infiltration, part of multimodal analgesia, in bilateral total knee arthroplasty.

To study plasma concentration of bupivacaine in patient who received spinal anesthesia and single shot bilateral adductor canal block and periarticular infiltration with bupivacaine for safety level.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Bupivacaine; Epinephrine; Epinephryl borate; Ketorolac; Ketorolac Tromethamine; Racepinephrine

Criteria

Inclusion Criteria:

• Aged more than 18 years old

• American society of anesthesiologists physical status classification 1-3

• Undergoing bilateral total knee arthroplasty with spinal anesthesia and single shot bilateral adductor canal block

Exclusion Criteria:

• Allergy to bupivacaine

• Body weight less than 50 kilograms

• Hepatic disease

• Coagulopathy

• Creatinine clearance less than 60 ml/min

• Uncontrolled cerebrovascular disease

• Hematocrit less than 35%