Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient

• Status: Completed
• Trial end date: 2012-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate whether a therapy that uses a machine called a continuous high frequency oscillator (CHFO) is more successful at removing mucus than medications that thin out the mucus.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Acetylcysteine; Expectorants; N-monoacetylcystine

Criteria

Inclusion Criteria:

1. Informed consent from parent or legal guardian.

2. Age < 18 years and admitted to the PICU or PCICU.

3. Conventionally ventilated.

4. Mucolytics are being initiated by clinical team for treatment of atelectasis.

5. Endotracheal tube ≥ 3.5 mm internal diameter.

Exclusion Criteria:

1. Receiving chronic mucolytic or continuous high frequency oscillation therapy.

2. Clinically significant pleural effusion.

3. Status post cardiothoracic surgery with open chest.

4. Pneumothorax.

5. Pulmonary hemorrhage.

6. Escalating doses of vasoactive agents (i.e. dopamine or epinephrine).