Efficacy of Pimozide Augmentation for Clozapine Partial Response
Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
This is a 12 week outpatient study for patients with schizophrenia who are on Clozapine, but
continue to experience symptoms. The purpose of this project is to find out if small doses of
pimozide (an antipsychotic medication, taken by mouth) will be helpful in reducing symptoms
(such as hearing voices, having trouble in organizing your thoughts, lack of interest in life
events and social activities), compared to placebo (an inactive substance, "sugar pill"),
when added to clozapine in patients with schizophrenia.
The participant will be asked to come in once a week to meet with the research staff and
study doctor. The participant will continue to see your regular clinician during this study
for all normal appointments. The participant will remain on your current medications
throughout the study. During the study you will be randomly selected to be put on a small
dose of Pimozide or placebo.