Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine efficacy of preoperative IV dexamethasone for postoperative pain control after TKA.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thammasat University
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty

• 50-85 years old

• ASA class 1-3

Exclusion Criteria:

• Unable to perform spinal anaesthesia

• History of drug allergies: steroids

• Renal impairment (CrCl <30 mL/min)

• Liver impairment

• Cognitive function disorders

• Poor controlled DM (HA1C > 7.5)

• Morning DTX at operative day > 180 mg%

• Received corticosteroids within 3 months before surgery