Efficacy of Probiotic Capsules With Topical Clobetasol Propionate in OLP Treatment
Status:
Recruiting
Trial end date:
2023-12-30
Target enrollment:
Participant gender:
Summary
Oral lichen planus patients who will meet inclusion criteria will be divided into 2 groups
-The intervention group (Group P): This group will be randomly allocated to take one capsule
twice daily during meal time at morning and evening of probiotics complex obtained from
Biovea for 4 -week study period. Moreover, patients in this group will be instructed to apply
clobetasole propionate in orabase gel 2 times daily for 4 weeks. Patients will receive their
supply of the gel and probiotics every 2 weeks. The control group (Group B): This group will
be randomly allocated to apply clobetasol propionate in orabase gel 4 times daily after meal
times and before sleeping for 4 weeks. At the 3rd week this group will be instructed to apply
miconazole gel 4 times daily as a prophylaxis for two weeks.
Salivary sample collection: Unstimulated salivary sample was collected from all participants
twice , once at baseline and another time after 4 weeks from the study period. Saliva was
collected in graduated clear test tubes to be used in the evaluation of candidal counts
before and after treatment .
Patient's visits was at baseline, 2 weeks and 4 weeks.