Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome

• Status: Unknown status
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: Male

Summary

To investigate the hormone response of hypothalamic-pituitary-gonad axis and spermatogenesis in male pituitary stalk interruption syndrome patients by pulsatile GnRH therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking Union Medical College Hospital
• Treatments: Hormones

Criteria

Inclusion Criteria:

• 18 years or over male patients;

• Absent or incomplete puberty development;

• Serum testosterone values below 3.47 nmol/L by low or normal serum LH and FSH concentrations.

• at least two or more pituitary hormone deficiencies

• Brain MRI showed absent and thin pituitary stalk, or pituitary hypoplasia and/or ectopic posterior pituitary.

Exclusion Criteria:

• cryptorchidism history

• other causes of hypopituitarism or severe systemic disease