Efficacy of Roflumilast in Prevention of Peripheral Neuropathy
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
There are several mechanisms concerning pathophysiology of paclitaxel induced peripheral
neuropathy. One of the main mechanisms is induction of Schwann cell dedifferentiation by
paclitaxel. At the preclinical level, roflumilast potently inhibited paclitaxel-induced
dedifferentiation of cultured Schwann cells, yet this positive effect have not been
clinically investigated.