Efficacy of Statins In Prevention of CIN

• Status: Terminated
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine if statin therapy plus intravenous normal saline, in patients with chronic renal insufficiency undergoing angiography, is superior to placebo plus intravenous normal saline therapy in the prevention of CIN.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oklahoma
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

1. Inclusion Criteria:

• Adults > 18 years of age

• undergoing coronary or peripheral angiography with or without intervention

• Cr > 1.3 mg/dL or GFR < 60 mL/min

2. Exclusion Criteria:

• end-stage renal disease on dialysis

• acute renal failure

• previous iodinated contrast media exposure within 7 days of study entry

• history of hypersensitivity to statins

• pregnancy or lactation

• emergent coronary angiography, ST elevation myocardial infarction (STEMI), or cardiogenic shock

• prisoners

• patients already on maximum dose of statins

• patient receiving N-acetylcysteine or sodium bicarbonate